Sensohaler Monitors Inhaler Function And Use

Sagentia has brought out the Sensohaler inhaler-compliance monitoring technology. Sensohaler uses advanced acoustic analysis to examine how an inhaler is functioning and how it is being used by the patient. It provides valuable feedback to the user, doctor or provider and consequently promotes correct use. It increases compliance through positive user feedback, helps doctors to understand the efficacy of the medication and helps drug providers learn how their products perform early on in clinical trials.

The technology comprises a microphone sensor and a chip for signal analysis that would sit in or on the inhaler. It accurately measures and monitors key performance characteristics - such as flowrate, inhaled volume and peak inspiratory flowrate - during the inspiratory manoeuvre and confirms events such as the firing of a breath actuation mechanism (BAM) and delivery of the formulation through the airway of the device. The technique is non-invasive, has no effect on the airflow or the aerosolisation performance of the inhaler and (if required) can be imperceptible to the user.

A feasibility study using Sensohaler demonstrated the accuracy of the technology on a range of different devices and inhaler types. It proved with two different inhaler types that the flowrate accuracy is on par with that of a thermal mass flowmeter. 'Non compliance in inhaled drug delivery is a big issue. 'Providing direct feedback to users will help reinforce correct usage and also assist clinicians in working with their patients to improve management of their disease,' said Iain Simpson, head of Sagentia's drug-delivery team. The Sensohaler technology is currently being demonstrated on Sagentia's stand at the Respiratory Drug Delivery (RDD) Conference, being held 25-29 April in Orlando.

The conference includes in-depth discussions of the issues surrounding aerosol drug delivery, including new therapeutic opportunities and drug-design technologies, progress in drug development alongside novel in vitro and in vivo testing methods and regulatory science. Visitors to Sagentia's stand will have the chance to take part in its 'Test your Lung Power' challenge, using another technology demonstrator used to characterise lungs against different constraints.


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